Prescription Drug Withdrawal Symptoms: What to Expect

March 20, 2025

Written By: Katie Noetzel, BSN, RN

 

Withdrawal from prescription medications is a complex process involving physical and psychological challenges. Whether experiencing drug withdrawal or noticing drug withdrawal symptoms from medications such as opioids or benzodiazepines, understanding these symptoms can help you better navigate this difficult phase of recovery.

At Buena Vista Recovery, we emphasize that safe management, including the use of evidence-based practice drug withdrawal medication and expert medical assistance, can make all the difference in overcoming substance withdrawal and achieving lasting recovery.

What Is Prescription Medication Withdrawal?

Prescription medication withdrawal results when the body reacts to the sudden discontinuation or gradual reduction of medications following prolonged usage or abuse. Despite adherence to prescribed directions, numerous medications can result in physical dependence, and sudden discontinuation or tapering may provoke a series of drug withdrawal symptoms. This reaction reflects not only the cessation of pharmacological effects but also signifies the body’s adaptation to the sustained presence of the medication. Early identification of these withdrawal symptoms is pivotal for the safe and effective management of this process.

Common Classes of Prescription Drugs That Can Cause Withdrawal

Different classes of medications may produce unique withdrawal experiences, some more serious substances require medical detox and others may not. Here are some key categories:

  1. Opioids (generally requires medical detox):
    Includes Oxycontin, Fentanyl, Hydromorphone, Hydrocodone, and Codeine, and Meperidine.
  2. Benzodiazepines (generally requires medical detox):
    Drugs such as Xanax, Ativan, and Valium.
  3. Antidepressants (does not require medical detox unless used with drugs that do):
    Citalopram (Celexa), Escitalopram (Lexapro), Fluoxetine (Prozac), Paroxetine (Paxil), and Sertraline (Zoloft).
  4. Stimulants (does not require medical detox unless used with drugs that do):
    Amphetamines (Adder- all and Dexedrine), methylphenidate (Concerta and Ritalin).

General Symptoms of Prescription Medication Withdrawal

The withdrawal symptoms experienced during prescription medication withdrawal can vary widely based on the substance, dosage and the person’s overall health. In many cases, drug withdrawal symptoms may include:

  1. Physical symptoms:
    Nausea, sweating, headaches, muscle aches, and gastrointestinal distress.
  2. Psychological symptoms:
    Anxiety, depression, irritability, and mood swings.
  3. Severe symptoms:
    In some cases, complications may arise that could be life-threatening, especially if a person with a significant substance use disorder attempts to withdraw without professional intervention.

Withdrawal Symptoms by Drug Type

Different classes of prescription drugs present unique challenges when discontinuing use. Here’s an overview of what you might expect based on the specific medication type:

Opioids

Withdrawal from opioids is notorious for its severity. Opiate and opioid withdrawal symptoms typically include intense flu-like symptoms, muscle aches, and anxiety. The timeline for these withdrawal symptoms may span from a few days to several weeks. Given the risk of relapse, especially in people with opioid dependence, it is best to avoid suddenly stopping your medication without a structured tapering plan from a medical professional. 

Benzodiazepines

Benzodiazepine withdrawal (or “benzo” withdrawal) can be particularly challenging, with many patients experiencing withdrawal symptoms such as severe anxiety, insomnia, and even seizures in extreme cases. Xanax withdrawal is a common example, where the abrupt discontinuation of the drug can be incredibly uncomfortable. Typically, withdrawal from prescribed benzodiazepines occurs over weeks or months, emphasizing the importance of gradual dose reduction under medical supervision.

Antidepressants

When discontinuing antidepressants, especially medications like Zoloft, many patients report withdrawal symptoms that include dizziness, nausea, and mood swings. The withdrawal process for antidepressants generally unfolds over a timeline that can extend from several weeks to months, requiring consultation with the prescribing healthcare provider to avoid exacerbating underlying mental health issues. Withdrawal from antidepressants should always be discussed with your provider to develop the best plan and monitoring.

Stimulants

Withdrawal from stimulant medications often manifests as fatigue, depression, increased irritability and changes in appetite. Although the symptoms of drug withdrawal in this category might not be as physically intense as those associated with opioids or benzodiazepines, the psychological impact can be significant. The timeline for recovery may vary depending on the duration of use and the specific substance involved but rarely requires inpatient detoxification.

Getting Medical Assistance

Attempting to manage prescription drug withdrawal on your own can be difficult and even life-threatening. Without proper medical assistance, the withdrawal symptoms may escalate, potentially jeopardizing both your physical and mental health. Supervised medical detox programs can offer a controlled environment where healthcare providers can administer safe and effective drug withdrawal medication to alleviate discomfort and reduce risks associated with severe substance withdrawal symptoms of certain classes of medication. This type of support is known as Medication-Assisted Treatment (MAT), and is a specialty at Buena Vista Recovery. Additionally, professional support is essential for addressing co-occurring substance use disorders.

The Process of Withdrawing from Prescription Medications

A successful withdrawal process involves several carefully coordinated steps:

  1. Assessment
    A comprehensive evaluation of your overall health, medication history, and any substance use issues is conducted. This helps in understanding the extent of your physical dependence and prepares your care team to address any underlying mental health concerns.
  2. Supportive Medication
    We minimize the onset of severe drug withdrawal symptoms by replacing your prescribed medications with supportive ones like Suboxone or Ativan, and then slowly reduce (taper) those drugs.
  3. Supportive Care
    During the detox process, supportive measures—such as nutritional guidance, hydration, and rest—are provided. This step helps manage both the physical and emotional challenges of drug withdrawal.
  4. Addressing Co-Occurring Disorders
    Many people facing prescription medication withdrawal also struggle with substance use disorders or other mental health conditions. Simultaneous treatment and ongoing support ensure a holistic approach to recovery.

Long Term Recovery

Successfully managing drug withdrawal is only the first step toward a healthier future. In the long term, proper detoxification sets the stage for improved overall health and better outcomes in addiction treatment. Long term recovery strategies include:

  • Therapeutic Support:
    Engaging in addiction recovery therapy, including individual therapy, group sessions, and support groups helps to maintain mental health and prevent relapse.
  • Relapse Prevention:
    • Creating a relapse prevention plan with strategies to cope with cravings and triggers is key. This proactive approach can help individuals, including those labeled as addicts in the past, avoid falling back into harmful patterns.
    • Medication Assisted Treatment (MAT) provides ongoing medication to reduce substance use cravings and improved treatment retention.
  • Continued Medical Monitoring:
    Follow-up care is critical to address any lingering withdrawal symptoms and to support ongoing recovery efforts.

Maintaining a focus on mental health and robust aftercare ensures that recovery is sustainable over the long term.

Start Your Journey to Recovery

Understanding and managing prescription medication withdrawal safely is vital for anyone facing the challenges of drug withdrawal. Whether you’re dealing with opioid, benzo, or alcohol withdrawal symptoms, professional medical assistance is the cornerstone of a safe detox process. At Buena Vista Recovery, our tailored programs offer comprehensive care—from a thorough assessment to supportive medication treatment with gradual tapering to supportive aftercare—all designed to minimize substance withdrawal symptoms and set you on the path to lasting recovery. 

If you or a loved one is struggling with physical dependence on prescription medications, don’t hesitate to reach out for expert help. Your journey to recovery begins with taking the first step toward a healthier, long-term future.

Contact a Buena Vista Treatment Advisor today at (602) 902-1112 to start your recovery journey.

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Sources:

  1. https://www.ncbi.nlm.nih.gov/books/NBK459239/#:~:text=Withdrawal%20syndromes%20occur%20when%20the,substance%20and%20duration%20of%20use
  2. https://www.ncbi.nlm.nih.gov/books/NBK526012/
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC1711840/
  4. https://pubmed.ncbi.nlm.nih.gov/7841856/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC5449237/
  6. https://www.ncbi.nlm.nih.gov/books/NBK576550/

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